Scientific Study of Anadrol

Anadrol (Oxymetholone) is getting very popular in Sri Lanka for some reason and I got so many inquiries about this drug in the past few weeks. People ranging from ages 20s to late 40s.This drug was first introduced in 1959. [1]

In rat and rabbit skeletal muscle androgen receptors, oxymetholone binds to the receptor extremely weakly, suggesting that it may exert its influence via metabolites or other receptors

I will first talk about the dangers of this drug and in a later article I will explain how to use this drug as safely as possible according to the research I have done over the past few years

Side Effects.

Within 6 weeks, oxymetholone has produced hypertriglyceridemia and hyperlipidemia in a patient (as well as cerebral thrombosis) [2]

Oxymetholone causes free radical-induced testicular damage that can be attenuated with the use of antioxidant compounds. [3][4]

Cholestatic jaundice and hepatitis has occurred with oxymetholone use, causing some fatalities [5].

After discontinuation, oxymetholone has caused peliosis hepatis. [6][7]

Oxymetholone use is also associated with benign and malignant liver tumors [8]

Oxymetholone has caused acute renal failure due to rhabdomyolysis [9]

Oxymetholone can produce kidney damage (particularly to the glomeruli) in one day old rodents [10]

[1] Ringold, H. J., Batres, E., Halpern, O., & Necoechea, E. (1959). Steroids. CV. 1 2-Methyl and 2-hydroxymethylene-androstane derivatives. Journal of the American Chemical Society, 81(2), 427-432.

[2] Reeves, R. D., Morris, M. D., & Barbour, G. L. (1976). Hyperlipidemia due to oxymetholone therapy: Occurrence in a long-term hemodialysis patient. Jama, 236(5), 469-472.

[3] Akbari Bazm, M., Khazaei, M., Khazaei, F., & Naseri, L. (2019). Nasturtium Officinale L. hydroalcoholic extract improved oxymetholone‐induced oxidative injury in mouse testis and sperm parameters. Andrologia, 51(7), e13294.

[4] Akbari Bazm, M., Goodarzi, N., Shahrokhi, S. R., & Khazaei, M. (2020). The effects of hydroalcoholic extract of Vaccinium arctostaphylos L. on sperm parameters, oxidative injury and apoptotic changes in oxymetholone‐induced testicular toxicity in mouse. Andrologia, 52(3), e13522.

[5] Young, G. P., Bhathal, P. S., Sullivan, J. R., Wall, J. A. J., Fone, D. J., & Hurley, T. H. (1977). Fatal hepatic coma complicating oxymetholone therapy in multiple myeloma. Australian and New Zealand journal of medicine, 7(1), 47-51.

[6] McDonald, E. C., & Speicher, C. E. (1978). Peliosis hepatis associated with administration of oxymetholone. JAMA, 240(3), 243-244.

[7] Arnold, G. L., & Kaplan, M. M. (1979). Peliosis hepatis due to oxymetholone--a clinically benign disorder. American Journal of Gastroenterology, 71(2).

[8] Velazquez, I., & Alter, B. P. (2004). Androgens and liver tumors: Fanconi's anemia and non‐Fanconi's conditions. American journal of hematology, 77(3), 257-267.

[9] Elyasi, F. (2018). Oxymetholone-induced acute renal failure: a case report. Caspian Journal of Internal Medicine, 9(4), 410.

[10] Karimi Jashni, H., Bandak, S., & Mahjoor, A. (2011). The effect of oxymetholone on the kidney tissues of one day old rats. Journal of Jahrom University of Medical Sciences, 9(3), 8-13.